Cheap Flights from Medellin (MDEA) to Guayaquil (GYE)

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Flight deals from Medellin to Guayaquil Airport

Looking for a cheap last-minute deal or the best return flight from Medellin to Guayaquil Airport? If you want to travel next month, return fares start from £289. Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Medellin to Guayaquil

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Medellin to Guayaquil flights are currently cheapest in April.

Direct flights from Medellin to Guayaquil

Medellin to Guayaquil: Alternative routes

Compare routes from Medellin to Guayaquil below. You may find an airport to fly into that's cheaper, faster, or easier than Guayaquil.

Medellin to Guayaquil: Flight information

The things to know before you go.
Cheapest flight found£167
Cheapest month to flyApril
Average flight time2 hrs
Most popular airlineAvianca Ecuador
Average flights per week6

Finding cheap flights from Medellin to Guayaquil: Frequently asked questions

The best price we found for a return flight from Medellin to Guayaquil is £289. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
2 hours is the average flight time from Medellin to Guayaquil.
Avianca Ecuador and Avianca fly direct from Medellin to Guayaquil.
As of April 2026, there are 18 flights per week flying from Medellin to Guayaquil.
The cheapest month to fly from Medellin to Guayaquil is usually May.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Medellin to Guayaquil Airport on Friday, 15 May 2026.
Yes – the average flight time is 2 hours.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Guayaquil but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Guayaquil is around 40 days in advance, so don’t leave your flight to the last minute.
The cheapest airline that flies to Guayaquil is Avianca .

Flying from Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE): What you need to know

  • Planning your getaway begins with figuring out where you'll fly out of in Medellin. Medellin Jose Maria Cordova Intl Airport (MDE) is the city's main base, so explore your options for booking a flight from Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE) out of here.

  • Expect to be travelling for 1 hour 55 minutes. That's the average journey time for a direct Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport flight.

  • Medellin and Guayaquil (where Guayaquil Jose Joaquin de Olmedo Intl Airport is located) share the UTC-5 timezone. That means you won't have to adjust your watch once you arrive.

  • Medellin Jose Maria Cordova Intl Airport (MDE) to Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE) is the most popular route, with 3 direct services each week. You can get from MDE to GYE on AVIANCA's 4:55pm departure.

  • To ensure you get on your flight from Medellin to GYE, leave enough time to navigate the airport and find your gate. Arriving two hours before international departures and one hour before domestic flights is the general rule.

  • Head to the airport even earlier during popular months like January. Aim for two hours before a domestic departure and as much as four hours for an international flight. Once you've checked in, you can use any extra time to grab something to eat or simply relax.

Airports in Medellin

Medellin Jose Maria Cordova Intl Airport (MDE)

  • Get there in one go from Medellin Jose Maria Cordova Intl Airport (MDE). Nonstop flights from Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE) operate from here.

  • You can get away on a direct flight from Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport with AVIANCA. This top airline operates departures from MDE.

  • Avianca sees the most traveller bookings for flights from MDE to GYE.

  • Avianca is the leading carrier for punctuality on this route, with 92.0% of its services arriving on schedule.

  • MDE is around 32 kms (20 miles) from central Medellin. If you're driving, ride-sharing or catching a taxi from the centre, it'll take 45 minutes or so to get there, depending on traffic. If you're taking public transport, expect the trip time to be around 1 hour 15 minutes.

  • Have an early flight from Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport? Avoid the mad dash to the terminal (and sneak in some extra snooze time) by staying at one of these hotels near Medellin Jose Maria Cordova Intl Airport:

  • When it comes to the on-time performance of Medellin Jose Maria Cordova Intl Airport, data shows 76% of flights complete their journey on time.

Medellin Enrique Olaya Herrera Airport (EOH)

  • Break up your flight from Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport with a stop at Bogota El Dorado International Airport (BOG). A major connection between Medellin Enrique Olaya Herrera Airport and GYE, it's a great opportunity to unwind before the next leg of your journey.

  • With public transport, you can travel from central Medellin to EOH in around 25 minutes. The airport is roughly 5 kms (3 miles) away, and getting there by car will take approximately 15 minutes.

  • Get a head start on your holiday with an additional night away from home. Before your Medellin to GYE flight, kick back in one of these hotels near Medellin Enrique Olaya Herrera Airport:

About Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE)

  • If you have a late flight from Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport, few things beat the convenience of staying near the terminal. Pick up your luggage at baggage claim and then be showered and resting not long after at one of these options near GYE:

  • Lock in the best rate by reserving your vehicle around four weeks ahead of your Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport flight.

Getting from Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE) to central Guayaquil

  • From Guayaquil Jose Joaquin de Olmedo Intl Airport, central Guayaquil is around 8 kms (5 miles) away. It takes about 20 minutes to reach the city centre by car.

  • If you're using public transport, expect a journey of around 35 minutes.

How to find the cheapest flights from Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE)

  • The lowest price we've found for a one-way ticket from Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport is £167. For a return flight on this route, the best price is £289. Depending on the availability when you book, these fares may change.

  • Book nine months before travelling. Pricing trends suggest that this is the ideal window for finding cheap flights from Medellin to GYE.

  • The best month for scoring cheap Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport tickets is February. Use the 'Whole month' tool to compare flight prices, then choose the dates that offer the lowest fares.

  • You don't need to check every day to find out if fares have dropped when you create a Price Alert. We'll let you know the moment a better deal is available on plane tickets from Medellin to GYE.

  • Filters make it easier to snap up a deal on your flight from Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport. Pick the departure times, airlines and number of stops that look good to you. Then sort the results by 'Cheapest' to find the lowest price right away.

The best time to fly from Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE)

  • Picture the kind of break you want when deciding your trip dates. December is the quietest month to visit Guayaquil. July is when most people book flights from Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE), which may be ideal if you're chasing more excitement.

  • When booking your Medellin to GYE plane ticket, consider the type of weather you enjoy. November is the warmest month in Guayaquil, with temperatures ranging from 19ºC to 33ºC.

  • Look for cheap tickets from Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport in August if you'd rather travel when it's cooler. Temperatures are at their lowest then, ranging between 19ºC and 32ºC.

More about Guayaquil

  • Once you've booked your flight from Medellin to Guayaquil Jose Joaquin de Olmedo Intl Airport, find a hotel that's got location and comfort covered. Make one of these accommodation options your base for exploring Guayaquil:

  • Amazon Rainforest and Crystal Palace are just the start of the top attractions to put on your Guayaquil to-do list. Keep the momentum going by heading to Malecon 2000.

Explore more of Ecuador

  • Quito is just one of the many cities in Ecuador waiting to be explored once you've seen the sights of Guayaquil. Around 274 kms (170 miles) away to the northeast, well-known attractions include Quito Historic Centre, Catedral Metropolitana de Quito and Camino de los Incas.

  • If you're ready to explore another major stop in Ecuador, head for Cuenca, roughly 129 kms (80 miles) southeast of Guayaquil. Inca Ruins, New Cathedral (Catedral de la Immaculada) and Old Cathedral of Cuenca are among its highlights.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.