Cheap Flights from Knoxville (TYS) to St Louis (STL)

Compare Knoxville to St Louis flight deals

Find the cheapest month or even day of the year to fly to St Louis

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Flight deals from Knoxville Airport to St Louis Airport

Looking for a cheap last-minute deal or the best return flight from Knoxville Airport to St Louis Airport? If you want to travel next month, return fares start from £202. Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Knoxville to St Louis

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Knoxville to St Louis flights are currently cheapest in April.

Knoxville to St Louis: Alternative routes

Compare routes from Knoxville to St Louis below. You may find an airport to fly into that's cheaper, faster, or easier than St Louis.

Knoxville to St Louis: Flight information

The things to know before you go.
Cheapest flight found£83
Cheapest month to flyApril

Finding cheap flights from Knoxville to St Louis: Frequently asked questions

The best price we found for a return flight from Knoxville to St Louis is £201. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Knoxville to St Louis. But we found flights with one or more stops from £201.
As of April 2026, there are no flights flying from Knoxville to St Louis.
The cheapest month to fly from Knoxville to St Louis is usually April.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Knoxville Airport to St Louis Airport on Thursday, 23 April 2026.
No airlines currently offer direct flights between Knoxville Airport and St Louis Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to St Louis but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to St Louis is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Allegiant Air offers the cheapest flight tickets to St Louis.

Flying from McGhee Tyson Airport (TYS) to Lambert-St. Louis International Airport (STL): what you need to know

  • St Louis is one hour behind Knoxville and follows the UTC-5 timezone.

  • For a smooth journey, arrive at the airport two hours ahead of international flights and an hour before domestic departures. This way, you'll have plenty of time to board your TYS to STL flight.

  • Flying during a peak month like July? Public holidays and other popular seasons can mean longer queues at check-in and security. Be extra cautious and arrive up to four hours before an international flight and two hours before a domestic departure.

How to find the cheapest flights from McGhee Tyson Airport (TYS) to Lambert-St. Louis International Airport (STL)

  • Right now, £83 is the cheapest price we've found for a one-way McGhee Tyson Airport to Lambert-St. Louis International Airport flight. The best price for a return plane ticket is £201. Remember that fares could change due to demand when booking.

  • Don't leave everything to the last moment. You're more likely to find cheap tickets from TYS to STL if you book early. Airlines often have some terrific early bird rates.

  • The 'Whole month' tool shows you the cheapest flights from McGhee Tyson Airport to Lambert-St. Louis International Airport throughout the entire month. It's an easy way to find a bargain if your trip dates are flexible.

  • Spend less time searching for cheap flights from TYS to STL by setting up a Price Alert. We'll send you an email or notification through the app when a new low fare is offered.

  • Tailor your trip with filters. Pick your preferred departure and arrival times, total journey duration and airlines. You can also sort the results by 'Fastest,' 'Cheapest' or 'Best' flights from McGhee Tyson Airport to Lambert-St. Louis International Airport.

Handy information about McGhee Tyson Airport (TYS)

  • TYS is located at 2055 Alcoa Highway.

  • When it comes to the on-time performance of McGhee Tyson Airport, 78.98% of flights complete their journey on time.

  • To get to McGhee Tyson Airport from central Knoxville, it takes about 20 minutes by car. This depends on traffic though. It's approximately 14 miles from the airport to the city centre.

  • Get your break off to a hassle-free start by staying near TYS. Whether you're taking an early flight from McGhee Tyson Airport to Lambert-St. Louis International Airport or want to avoid feeling rushed, these stays are perfect:

Arriving at Lambert-St. Louis International Airport (STL)

Getting from Lambert-St. Louis International Airport (STL) to central St Louis

  • The street address for STL is 10701 Lambert International Blvd..

  • Lambert-St. Louis International Airport is roughly 16 miles from central St Louis. Driving there takes about 20 minutes.

  • It'll take around 35 minutes to get there using public transport.

When to fly to Lambert-St. Louis International Airport (STL)

  • The quietest month for a flight from McGhee Tyson Airport to Lambert-St. Louis International Airport is April, while July is the most popular. Choose the ideal time to go to St Louis based on whether you prefer a bustling atmosphere or a more laid-back vibe.

  • The warmest month in St Louis is July, with temperatures ranging between 17ºC (63ºF) and 33ºC (91ºF). Lock in your flights from McGhee Tyson Airport to Lambert-St. Louis International Airport in this month if you enjoy this type of weather.

  • January has average temperatures of between -8ºC (18ºF) and 7ºC (45ºF). Look for cheap tickets from TYS to STL around that time if you want to travel in cooler conditions.

Explore more of United States

  • You've visited St Louis, now it's time to explore other parts of United States. Journey around 260 miles north-east to Chicago to check off its top sights. From Millennium Park to Art Institute of Chicago and LandShark Beer Garden at Navy Pier, you've got a jam-packed schedule ahead.

  • Indianapolis is another must-experience destination in United States and is around 230 miles east of St Louis. No trip is complete without a visit to The Children's Museum of Indianapolis, Indianapolis Museum of Art and Indianapolis Zoo.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.